platelet dense granules
Of these alpha granules are the most common making up between 50 to 80 of the secretory granules. Human platelets possess an organelle the dense granule with morphological and biochemical similarities to acidocalcisomes.
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These membrane proteins are translocated to the cell surface upon platelet activation.
. Dense granules contain the lysosomal membrane proteins CD63 and LAMP12 20 but also non-lysosomal proteins such as P-selectin GPIb and αII-β3 integrin 20. 311125155 the most commonly used method for assessing platelet dense granule release is a bioluminescent assay that uses d-luciferin and firefly luciferase to measure atp release in response to agonist stimulation usually. Alpha granules α-granules also known as platelet alpha-granules are a cellular component of platelets.
Dense granules contain rab27a and b 21 22 two small GTP- ases required for content release. Platelets contain three to eight dense granules storing high concentrations of cations Ca2 Mg 2 K polyphosphate nucleotides ADP ATP GTP and bioactive amines serotonin and histamine. Platelet dense granules store extremely high concentrations of calcium together with ATP ADP serotonin and PP i 8.
Holmsen and Weiss 9 calculated the intragranular calcium concentration to be 22 m. The release of platelet dense granule contents can be monitored as part of wba or lta assays figs 28-1 and 28-2. Platelets contain different types of granules that perform different functions and include alpha granules dense granules and lysosomes.
These granules are innately dense when viewed by electron microscopy due to.
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